Peptides that influence DNA repair mechanisms, cellular senescence, and mitochondrial biogenesis across aging models.
Comprehensive review and gene-array profiling detailing how GHK-Cu resets gene expression in human fibroblasts toward a younger phenotype and accelerates cutaneous wound closure.
The groundbreaking Cell Metabolism discovery paper isolating the mitochondrial hormone MOTS-c, demonstrating systemic metabolic reprogramming, AMPK phosphorylation, and reversal of insulin resistance.
Foundational laboratory investigation demonstrating that the pineal tetrapeptide Epithalon overcomes somatic cellular senescence by reactivating telomerase expression and elongating telomeres.
Multicenter randomized trial demonstrating that thymosin alpha-1 immunotherapy reduces 28-day all-cause mortality from 35.0% to 26.0% in patients with severe sepsis and immune paralysis.
Translational aging study showing that the cardiolipin-targeted peptide SS-31 reverses mitochondrial energy deficits and restores contractile force in aged musculoskeletal tissue.
