Authors: Campbell MD, Duan J, Samuelson AT, et al.
Non-Human Preclinical Study Notice
This publication investigates biological mechanisms in animal models or isolated cell cultures. Findings cannot be directly extrapolated to human safety, efficacy, or pharmacokinetics without formal clinical trial confirmation.
Restoration of mitochondrial maximum ATP production rate and 32% increase in muscle endurance
Mitochondrial dysfunction characterized by cristae disorganization and excessive ROS contributes to age-related sarcopenia. Here we demonstrate that the cardiolipin-binding peptide SS-31 (elamipretide) administered to aged mice for 8 weeks restored mitochondrial ATP generation capacity, normalized complex I/III electron flux, reduced protein carbonyl oxidation by 45%, and significantly restored in vivo muscle contractile force and endurance.
Translational aging study showing that the cardiolipin-targeted peptide SS-31 reverses mitochondrial energy deficits and restores contractile force in aged musculoskeletal tissue.
* Educational commentary prepared by Peptide Health Digest editors to provide context on study methodology.
Campbell MD, Duan J, Samuelson AT, et al.
This study record was compiled from public biomedical repositories for educational and informational reference. Peptide Health Digest does not claim authorship of the original investigation.
