Authors: Khavinson VK, Bondarev IE, Butyugov AA.
Non-Human Preclinical Study Notice
This publication investigates biological mechanisms in animal models or isolated cell cultures. Findings cannot be directly extrapolated to human safety, efficacy, or pharmacokinetics without formal clinical trial confirmation.
Measurable telomere elongation and extension of proliferative lifespan by ~10 doublings
The effect of the synthetic pineal tetrapeptide Epithalon on telomerase activity and telomere length was studied in human somatic fibroblast cell cultures approaching the Hayflick limit. Epithalon induced telomerase gene expression (hTERT) and led to measurable elongation of telomeric repeat sequences, enabling cells to overcome replicative senescence and execute an additional 10 population doublings.
Foundational laboratory investigation demonstrating that the pineal tetrapeptide Epithalon overcomes somatic cellular senescence by reactivating telomerase expression and elongating telomeres.
* Educational commentary prepared by Peptide Health Digest editors to provide context on study methodology.
Khavinson VK, Bondarev IE, Butyugov AA.
This study record was compiled from public biomedical repositories for educational and informational reference. Peptide Health Digest does not claim authorship of the original investigation.
