A synthetic pineal-derived tetrapeptide researched for activating telomerase, restoring melatonin rhythms, and extending lifespan in somatic and cellular models.
~30 - 45 minutes (rapid intracellular genomic signaling)
Telomerase (hTERT) Promoter
C14H22N4O9
Investigated primarily via subcutaneous injection in intermittent cyclical protocols.
Small or observational human data; warrants clinical caution.
Animal (rodent) and in-vitro cellular assays. Does NOT prove human efficacy.
Formal regulatory oversight and verified clinical development phase.
Evidence classification for Epithalon: Human clinical data is strictly differentiated from non-human animal and in-vitro laboratory assays.
C14H22N4O9
Ala-Glu-Asp-Gly
Epithalon (also known as Epitalon or AGAG) is a synthetic peptide modeled on Epithalamin, a peptide bioregulator extracted from the bovine pineal gland by Professor Vladimir Khavinson. Groundbreaking Russian gerontological research spanning three decades demonstrated that Epithalon induces telomerase catalytic subunit (hTERT) transcription, elongating telomeres in human somatic cells and overcoming the Hayflick cellular division limit.
Epigenetically reactivates dormant telomerase enzyme expression, promotes telomeric DNA elongation, protects chromosomes from oxidative degradation, and modulates pineal neuroendocrine circadian rhythms.
Peer-reviewed publications, clinical trials, and preclinical research investigating Epithalon.
Foundational laboratory investigation demonstrating that the pineal tetrapeptide Epithalon overcomes somatic cellular senescence by reactivating telomerase expression and elongating telomeres.
Documented literature dosing intervals and published clinical trial protocols.
Frequency: Daily for 10-20 consecutive days
“Classical Russian gerontological protocol administered in 10-20 day cycles twice annually.”
Frequency: Daily for 10-20 consecutive days
“Classical Russian gerontological protocol administered in 10-20 day cycles twice annually.”
Biological delivery routes and standardized laboratory reconstitution principles.
Investigated primarily via subcutaneous injection in intermittent cyclical protocols.
Lyophilized peptides must be reconstituted using sterile bacteriostatic water (0.9% benzyl alcohol) and maintained strictly refrigerated between 2°C - 8°C (36°F - 46°F), shielded from light.
View Full Preparation ProtocolHigh-throughput DNA methylation analysis evaluates whether pineal and thymic bioregulatory peptides alter cellular epigenetic age estimates.
Read ArticleCompiled from peer-reviewed biomedical literature, public clinical trial registries, and recognized reference catalog databases.
Pharmacological profiles, receptor targets, and clinical data are verified against primary registries:
Community research topics, peptide nomenclature, and aliases are cross-referenced with public catalogs:
This topic was identified through research of publicly available peptide resources and peer-reviewed literature. Peptide Health Digest provides independent scientific explanations and does not endorse commercial distribution.
