Comprehensive repository of peer-reviewed clinical trials and preclinical publications investigating Semax.
The effects of the ACTH(4-10) heptapeptide analog Semax on the expression of neurotrophin genes (Bdnf, Ngf, Ntf3) and neurotrophin receptors (Ntrk1, Ntrk2) were analyzed in rat brain tissues after permanent middle cerebral artery occlusion. Real-time PCR and Western blot demonstrated that Semax rapidly upregulated hippocampal and cortical BDNF mRNA and protein expression during the acute phase (up to 3-fold), promoting neuronal survival and microglial stabilization.
