A selective pentapeptide ghrelin receptor agonist that stimulates growth hormone release with minimal impact on cortisol, prolactin, or aldosterone.
~2 hours
GHS-R1a (Ghrelin Receptor)
C38H49N9O5
Administered via subcutaneous injection.
Small or observational human data; warrants clinical caution.
Animal (rodent) and in-vitro cellular assays. Does NOT prove human efficacy.
Formal regulatory oversight and verified clinical development phase.
Evidence classification for Ipamorelin: Human clinical data is strictly differentiated from non-human animal and in-vitro laboratory assays.
C38H49N9O5
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Ipamorelin is considered one of the cleanest growth hormone secretagogues (GHS) due to its high receptor selectivity. Unlike earlier secretagogues (such as GHRP-6 or GHRP-2), Ipamorelin does not induce significant elevations in ACTH, cortisol, or prolactin, nor does it cause severe hunger spikes.
Selectively activates the pituitary growth hormone secretagogue receptor 1a (GHS-R1a), triggering an intracellular IP3/calcium signaling cascade that prompts GH vesicle exocytosis.
Peer-reviewed publications, clinical trials, and preclinical research investigating Ipamorelin.
Documented literature dosing intervals and published clinical trial protocols.
Biological delivery routes and standardized laboratory reconstitution principles.
Administered via subcutaneous injection.
Lyophilized peptides must be reconstituted using sterile bacteriostatic water (0.9% benzyl alcohol) and maintained strictly refrigerated between 2°C - 8°C (36°F - 46°F), shielded from light.
View Full Preparation ProtocolCompiled from peer-reviewed biomedical literature, public clinical trial registries, and recognized reference catalog databases.
Pharmacological profiles, receptor targets, and clinical data are verified against primary registries:
Community research topics, peptide nomenclature, and aliases are cross-referenced with public catalogs:
This topic was identified through research of publicly available peptide resources and peer-reviewed literature. Peptide Health Digest provides independent scientific explanations and does not endorse commercial distribution.
