Comprehensive repository of peer-reviewed clinical trials and preclinical publications investigating MOTS-c.
Mitochondria produce regulatory peptides with systemic hormonal roles. Here, we report the identification of MOTS-c, a 16-amino acid peptide encoded in the mitochondrial 12S rRNA gene. MOTS-c targets skeletal muscle, where it inhibits the folate cycle and de novo purine synthesis, leading to AICAR accumulation and AMPK activation. MOTS-c treatment reversed high-fat-diet-induced insulin resistance and prevented diet-induced obesity in mouse models.
