Authors: George JT, Seminara SB, George JT, et al.
Immediate and robust dose-dependent rise in circulating LH pulse amplitude and frequency
Kisspeptin is an essential upstream activator of GnRH release. We investigated the neuroendocrine response to bolus and continuous intravenous kisspeptin-10 administration in healthy men. Intravenous kisspeptin-10 elicited a rapid, dose-dependent release of luteinizing hormone (LH) and pulse frequency increase within 15 minutes, validating kisspeptin as a potent non-pituitary neuroendocrine regulator of the human reproductive axis.
Clinical endocrine study establishing that intravenous kisspeptin-10 administration rapidly stimulates hypothalamic GnRH and pituitary LH secretion without downstream endocrine receptor exhaustion.
* Educational commentary prepared by Peptide Health Digest editors to provide context on study methodology.
George JT, Seminara SB, George JT, et al.
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