Pharmacokinetic parameters and nasal spray compounding considerations for neuropeptides such as Selank and Semax.
The olfactory nerve pathway and trigeminal neural networks provide a non-invasive conduit bypassing the blood-brain barrier (BBB). This allows hydrophilic peptide macromolecules direct access to the central nervous system within 5 to 15 minutes.
Standard clinical nasal spray actuators dispense a fixed volume of precisely 0.10 mL (100 microliters) per pump. When calculating concentration, ensure the total mass dissolved corresponds to the desired microgram dose per spray actuation.
